Studies on phenylalanine metabolism by tracer techniques. IV. Biotransformation of D- and L-phenylalanine in man.
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چکیده
منابع مشابه
Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria
Self-assembly of phenylalanine is linked to amyloid formation toxicity in phenylketonuria disease. We are demonstrating that L-phenylalanine self-assembles to amyloid fibrils at varying experimental conditions and transforms to a gel state at saturated concentration. Biophysical methods including nuclear magnetic resonance, resistance by alpha-phenylglycine to fibril formation and preference of...
متن کاملSynthesis of d‐ and l‐Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process†
The synthesis of substituted d-phenylalanines in high yield and excellent optical purity, starting from inexpensive cinnamic acids, has been achieved with a novel one-pot approach by coupling phenylalanine ammonia lyase (PAL) amination with a chemoenzymatic deracemization (based on stereoselective oxidation and nonselective reduction). A simple high-throughput solid-phase screening method has a...
متن کاملAmino Acid Isomerization in the Production of L-phenylalanine from D-phenylalanine by Bacteria.
To establish an advantageous method for the production of l-amino acids, microbial isomerization of d- and dl-amino acids to l-amino acids was studied. Screening experiments on a number of microorganisms showed that cell suspensions of Pseudomonas fluorescens and P. miyamizu were capable of isomerizing d- and dl-phenylalanines to l-phenylalanine. Various conditions suitable for isomerization by...
متن کاملThe utilization of L- and D-phenylalanine by the rat.
An investigation of the oxidation of phenylalanine has been undertaken in this laboratory in connection with studies of the hereditary defect phenylketonuria (phenylpyruvic oligophrenia), in which the oxidation does not occur in the normal manner. The biochemical defect is accompanied by a profound impairment of mental functioning (2, 3). A knowledge of the details of the oxidation might lead t...
متن کاملOn the metabolism of phenylalanine and tyrosine.
The metabolism of phenylalanine and tyrosine has been the subject of investigation for many years. Much evidence has been produced to show that in mammalian tissue phenylalanine is converted to tyrosine (l-5). Tyrosine can be oxidized to p-hydroxyphenylpyruvic acid, which can in turn form homogentisic acid (5-13). Embden, Salomon, and Schmidt (14) showed that phenylalanine, tyrosine, and homoge...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1981
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.29.514